ROLE OF ENDOGENOUS CCK IN REGULATION OF INTERDIGESTIVE PANCREATIC EXOCRINE SECRETION IN SHEEP (OVIS-ARIES)

The role of endogenous cholecystokinin (CCK) in the regulation of panc reatic exocrine secretion during the interdigestive period was studied in conscious sheep, Intravenous infusion of proglumide (15, 30 and 60 mu mol/kg/min) for 70 min significantly decreased flow rate, protein and amylase output in pancreatic juice by 80% at the maximum dose, as well as atropine (10 mu g/kg/min), without a significant decrease in p lasma concentration of immunoreactive CCK, Intravenous injection of CC K (114 pmol/kg) increased the pancreatic secretion during atropine inf usion, but not during proglumide infusion, These results suggest that the regulation of interdigestive pancreatic exocrine secretion in shee p depends greatly on endogenous CCK as well as on the cholinergic mech anism.