S. Tachibana et al., ROLE OF ENDOGENOUS CCK IN REGULATION OF INTERDIGESTIVE PANCREATIC EXOCRINE SECRETION IN SHEEP (OVIS-ARIES), Comparative biochemistry and physiology. Part A, Physiology, 112(1), 1995, pp. 103-109
The role of endogenous cholecystokinin (CCK) in the regulation of panc
reatic exocrine secretion during the interdigestive period was studied
in conscious sheep, Intravenous infusion of proglumide (15, 30 and 60
mu mol/kg/min) for 70 min significantly decreased flow rate, protein
and amylase output in pancreatic juice by 80% at the maximum dose, as
well as atropine (10 mu g/kg/min), without a significant decrease in p
lasma concentration of immunoreactive CCK, Intravenous injection of CC
K (114 pmol/kg) increased the pancreatic secretion during atropine inf
usion, but not during proglumide infusion, These results suggest that
the regulation of interdigestive pancreatic exocrine secretion in shee
p depends greatly on endogenous CCK as well as on the cholinergic mech
anism.