STUDY OF THE PHARMACOLOGICAL EFFECT OF THE BILE-SALT, SODIUM SCYMNOL SULFATE, FROM RHIZOPRIONODON ACUTUS - II - PROPHYLACTIC EFFECT OF SCYMNOL ON LESION DEVELOPMENT IN A RAT PERIPHERAL ARTERIAL-OCCLUSION MODEL

The effect of scymnol on the development of lesions in a rat periphera l arterial occlusion model, involving injection of 5% lactic acid into the femoral artery, was investigated. In this model oral administrati on of scymnol significantly prevented edematous swelling and developme nt of lower limb lesions, including gangrene, and also reduced changes in blood coagulation parameters, platelet aggregation and retention r ate at a dose of 10 ol 30 mg/kg. However, it had no effect on these cl otting system functions in sham-operated rats at a dose of 10 mg/kg. T he effects of scymnol were also compared with those of ticlopidine and argatroban. The findings suggest that scymnol may be clinically usefu l for preventing thrombotic peripheral arterial occlusive disorders. I ts prophylactic action appears to be mainly due to its potent ability to protect against endothelial cell damage due to lactic acidosis.