ANTIPROLIFERATIVE CONSTITUENTS IN UMBELLIFERAE PLANTS - II - SCREENING FOR POLYACETYLENES IN SOME UMBELLIFERAE PLANTS, AND ISOLATION OF PANAXYNOL AND FALCARINDIOL FROM THE ROOT OF HERACLEUM-MOELLENDORFFII

Methanol extracts of 36 samples of 21 Umbelliferae plants were screene d for polyacetylenic compounds using the ELISA for panaxytriol, and th eir antiproliferative activity was checked by MTT assay using the tumo r cell lines MK-1, HeLa and B16F10. The presence of antiproliferative polyacetylenes was suggested in Angelica acutiloba (fruit), Anethum gr aveolons (root), Bupleurum rotundifolium (fruit), Carum carvi (fruit a nd root), Coriandrum sativum (fruit), Cryptotaenia japonica (leaf), Gl ehnia littoralis (fruit), Heracleum moellendorffii (root) and Torilis japonica (fruit). Panaxynol and falcarindiol were successfully isolate d from the root of Heracleum moellendorffii as antiproliferative polya cetylenes.