M. Grilli et M. Memo, TRANSCRIPTIONAL PHARMACOLOGY OF NEURODEGENERATIVE DISORDERS - NOVEL VENUE TOWARDS NEUROPROTECTION AGAINST EXCITOTOXICITY, Molecular psychiatry, 2(3), 1997, pp. 192-194
Transcription factors NF-kappa B/Rel represent the point of convergenc
e of several signalling pathways relevant to neurodegeneration. The fi
nding that salicylates elicit neuroprotection via blockade of NF-kappa
B provides new opportunities for pharmacological intervention.