ASSOCIATION OF POLYMORPHISMS OF DOPAMINE D-2 RECEPTOR (DRD2), AND DOPAMINE TRANSPORTER (DAT(1)) GENES WITH SCHIZOID AVOIDANT BEHAVIORS (SAB)/

Authors
BLUM K BRAVERMAN ER WU S CULL JG CHEN TJH GILL J WOOD R EISENBERG A SHERMAN M DAVIS KR MATTHEWS D FISCHER L SCHNAUTZ N WALSH W PONTIUS AA ZEDAR M KAATS G COMINGS DE
Citation
K. Blum et al., ASSOCIATION OF POLYMORPHISMS OF DOPAMINE D-2 RECEPTOR (DRD2), AND DOPAMINE TRANSPORTER (DAT(1)) GENES WITH SCHIZOID AVOIDANT BEHAVIORS (SAB)/, Molecular psychiatry, 2(3), 1997, pp. 239-246
Citations number
79
Categorie Soggetti
Psychiatry,Biology
Journal title
Molecular psychiatry → ACNP
ISSN journal
13594184
Volume
2
Issue
3
Year of publication
1997
Pages
239 - 246
Database
ISI
SICI code
1359-4184(1997)2:3<239:AOPODD>2.0.ZU;2-4
Abstract
The dopaminergic system, and in particular the dopamine D-2 receptor, has been implicated in reward mechanisms in the brain. Dysfunction of the D-2 dopamine receptors leads to aberrant substance-seeking behavio rs (ethanol, drugs, tobacco, and food) and other related behaviors (pa thological gambling, Tourette's disorder, attention-deficit/hyperactiv ity disorder). This is the first study supporting a strong association between the dopamine D-2 receptor Tag A(1) allele with schizoid/avoid ant behavior (SAB). Additionally, an albeit weaker association between the 480-bp VNTR 10/10 allele of the dopamine transporter (DAT(1)) gen e with SAB was similarly found.