PANNICULITIS IN ASSOCIATION WITH APOMORPHINE INFUSION

This study was undertaken to ascertain the histopathology and aetiolog y of cutaneous nodules observed in Parkinson's patients treated with c ontinuous subcutaneous apomorphine. Ten patients were recruited. answe red questionnaires, and underwent skin biopsies and full blood count, and nine were patch tested to apomorphine and its preservative. Six ha d serum IgE levels measured. A florid panniculitis was seen in all bio psies; five were predominantly eosinophilic, three lymphocytic and two neutrophilic; in seven cases the panniculitis was mixed and in three it was septal. Patch testing was universally negative and the IgE leve ls were normal.