We report a 23-year-old Japanese man who had plantar warts on the righ
t sole, beneath one of which an epidermoid cyst developed. On microsco
pic examination, an acanthotic epidermis markedly invaginated into the
underlying dermis, resulting in an open epidermoid cyst. Not only the
polymerase chain reaction but also an in. situ hybridization detected
HPV 57 DNA in the cyst. HPV 60 is the only type of HPV that has been
identified in epidermoid cysts. To our knowledge, this is the first ca
se report of an epidermoid cyst, in which a different type of virus fr
om HPV 60 was identified. Histological features of the cyst were also
different from those of HPV 60-associated epidermoid cysts.