We report two patients who presented with increasing malaise and myalg
ia, and had biopsy-proven polymyositis. Their conditions deteriorated
after corticosteroid treatment, and repeat muscle biopsies showed adul
t and larval nematodes. Anthelminthic treatment was completely success
ful in both cases. The infecting nematode appears to belong to a new g
enus and is, to our knowledge, the first known muspiceoid nematode to
infect humans. Its life cycle and the route of infection are unknown.