CASE-REPORT - PINEOCYTOMA IN A MALE FISCHER-344 RAT

Citation
Je. Heath et Ts. Winokur, CASE-REPORT - PINEOCYTOMA IN A MALE FISCHER-344 RAT, Toxicologic pathology, 26(2), 1998, pp. 294-297
Citations number
18
Categorie Soggetti
Toxicology,Pathology
Journal title
ISSN journal
01926233
Volume
26
Issue
2
Year of publication
1998
Pages
294 - 297
Database
ISI
SICI code
0192-6233(1998)26:2<294:C-PIAM>2.0.ZU;2-2
Abstract
An enlarged pineal gland was observed in a 112-wk-old male Fischer 344 rat from the low-dose treatment group in a 2-yr bioassay. Formalin-fi xed, paraffin-embedded sections of the gland were stained with hematox ylin and eosin along with the immunohistochemical biomarkers synaptoph ysin, placental alkaline phosphatase, glial fibrillary acidic protein, and vimentin. Based on its histomorphological features and on positiv e staining with synaptophysin, the lesion was diagnosed as a malignant pineal gland parenchymal cell tumor or pineocytoma of incidental orig in.