D. Flagiello et al., NEAR HAPLOIDY IN BREAST-CANCER - A PARTICULAR PATHWAY OF CHROMOSOME EVOLUTION, Cancer genetics and cytogenetics, 102(1), 1998, pp. 54-58
In a series of 260 cytologically abnormal breast cancers studied in ou
r laboratory, we observed a single case of near-haploid karyotype: 27,
X, +der(1;16)(q10;p10), +7, +14, +15. A review of published cases of n
ear-haploid malignancies suggests that near haploidy belongs to a proc
ess of chromosome evolution distinct from that of most epithelial canc
ers in which hypodiploidy is strongly associated with the occurrence o
f unbalanced structural rearrangements. In near-haploid tumors, chromo
some loss is independent from chromosome rearrangements and may not be
associated with an adverse prognosis. (C) Elsevier Science Inc., 1998
.