TRISOMY-3 AS THE SOLE KARYOTYPIC CHANGE IN A PEDIATRIC IMMATURE TERATOMA

Authors
MERTENS F KULLENDORFF CM HJORTH L ALUMETS J
Citation
F. Mertens et al., TRISOMY-3 AS THE SOLE KARYOTYPIC CHANGE IN A PEDIATRIC IMMATURE TERATOMA, Cancer genetics and cytogenetics, 102(1), 1998, pp. 83-85
Citations number
15
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
102
Issue
1
Year of publication
1998
Pages
83 - 85
Database
ISI
SICI code
0165-4608(1998)102:1<83:TATSKC>2.0.ZU;2-G
Abstract
Cytogenetic analysis of short-term cultured cells from an immature ova rian teratoma of a 9-year-old girl disclosed an extra copy of chromoso me 3 as the sole clonal abnormality. The fact that trisomy 3 was previ ously reported as the only karyotypic change in two ovarian germ-cell tumors-one teratoma NOS and one immature teratoma-suggests that gain o f chromosome 3 constitutes an early and pathogenetically important cha nge in a subset of female germ-cell tumors. (C) Elsevier Science Inc., 1998.