PROTEIN A-IMMUNOADSORPTION IN CHEMOTHERAPY ASSOCIATED HEMOLYTIC-UREMIC SYNDROME

Authors
BORGHARDT EJ KIRCHERTZ EJ MARTEN I FENCHEL K
Citation
Ej. Borghardt et al., PROTEIN A-IMMUNOADSORPTION IN CHEMOTHERAPY ASSOCIATED HEMOLYTIC-UREMIC SYNDROME, Transfusion science, 19, 1998, pp. 5-7
Citations number
15
Categorie Soggetti
Hematology
Journal title
Transfusion science → ACNP
ISSN journal
09553886
Volume
19
Year of publication
1998
Supplement
S
Pages
5 - 7
Database
ISI
SICI code
0955-3886(1998)19:<5:PAICAH>2.0.ZU;2-T
Abstract
Circulating IgG-immune complexes (IgG-IC) play a role in the complex e tiology of C-HUS. In an ongoing open clinical study protein A immunoad sorption treatment is carried out fox patients who developed severe fo rms of the syndrome after mitomycin-C chemotherapy. So far, successful treatment of 14 out of 19 evaluable patients was possible. A protein A immunoadsorption system was used, allowing processing of large plasm a volumes to eliminate IgG and IgG-IC from the patient's plasma. (C) 1 998 Elsevier Science Ltd. All rights reserved.