EFFICACY OF MOXONIDINE, AN IMIDASOLINE RE CEPTOR AGONIST, IN PATIENTSWITH ESSENTIAL-HYPERTENSION

Aim. Study of zint (moxonidine), a hypotensive drug with the central m echanism of action. Materials and Methods. The hemodynamics and platel et functional activity were assessed in 30 patients with essential hyp ertension treated by tint in a daily dose of 0.4 mg, taken in the morn ing, for 3 months. Results. By the end of treatment the systolic arter ial pressure decreased by 23 +/- 4 mm Hg, diastolic by 15 +/- mm Hg, m ean pressure by 17 +/- 2 mm Hg, and heart rate by 5 +/- 4 str/min. Ech ography showed that myocardial hypertrophy decreased but negligibly. A n evident decrease of ADP-induced platelet aggregation was observed. C onclusion. Zint therapy may be a most physiological method of arterial hypertension control.