CLINICAL AND BIOCHEMICAL FEATURES OF THE MAIN RISK-FACTORS OF ATHEROSCLEROSIS IN THE CHILDREN OF PROBANDS WITH PRIMARY HYPERLIPIDEMIAS

Aim. Study of the incidence of hyperlipidemias and coronary atheroscle rosis risk factors. Materials and Methods. A clinical and biochemical study of 35 children (25 men and IO women aged 6 to 27 years) from 30 families of probands with primary hyperlipoproteinemias (HLP) was carr ied out. Use of modified risk factors (RF) in the examined group permi tted the detection of hypodynamia in 25 subjects, obesity in 4, alcoho l abuse and tobacco smoking in I, and disorders of lipid metabolism in 31 (88%) cases. Results. Hypercholesterolemia was detected in 26 exam inees, combined HLP in 1, hypoalphacholesterolemia in 3, and type V hy perlipoproteinemia in 1 case. The level of lipoprotein (a) was increas ed and positively col related with xanthomatosis and the age of examin ees. The level of basal immunoreactive insulin was within the normal r ange of values. Analysis of the relationship of this parameter and oth er coronary atherosclerosis RF revealed a correlation of the level of immunoreactive insulin and content of blood low-density lipoprotein ch olesterol. In only 2 of the 30 examined families of probands with prim ary HLP there were no disorders of lipid metabolism and other modified RF. Conclusion. Children, adolescents, and young people from families with primary HLP represent a risk group; they are to be regularly exa mined in order to prevent coronary disease and atherosclerosis and to detect and treat it in time.