ANTIOXIDANT PROBUCOL - EFFECTS ON FREE-RA DICAL LIPID-PEROXIDATION, BLOOD RHEOLOGY, AND COURSE OF ANGINA-PECTORIS

Aim. Study of the effect of antioxidant probucol on free-radical lipid peroxidation, blood rheology, and course of angina pectoris in corona ry patients. Materials and Methods. The above parameters and clinical hemodynamic values were monitored over the course of probucol therapy in 48 men (mean age 54.8 +/- 1.3 years) with coronary disease and angi na of effort of the II-lll functional class. Results. Long therapy wit h probucol effectively inhibited free-radical lipid peroxidation, norm alized lipid spectrum of the blood, and had a favorable impact on the course of angina pectoris. Conclusion. Probucol stabilizes the structu re and function of red cells and platelets in coronary patients.