PAROXYSMAL ACTIVITY TEST IN PEDIATRIC NEU ROLOGY

Taking into consideration the significance of glutamate receptors in e pileptic focus forming, the authors studied the level of autoantibodie s (Glu aAB) to fragment of glutamate receptors, quisqualate membrane p rotein with molecular mass 56 kDa in blood serum. The study employed t he diagnostic kit ''Paroxysmal activity test'' (PAT) elaborated in Ins titute of Human Brain, RAS (St-Petersburg). 140 children from 2 months to 16 years with epilepsy, epileptic syndrome, paroxysmal states of n onepileptic genesis and with other neurologic diseases as well practic ally healthy children were examined. Significant Increase of Glu aAB l evel was found in children epilepsy and epileptic syndrome as compared with healthy children. Glu aAB level was decreased in patients which were treated by adequate anticonvulsant therapy that resulted in relie f of convulsive fits for 6 months and normalization of EEG. In patient s with paroxysmal disorders Glu aAB content was lower than in patients with epilepsy and epileptic syndrome, but higher than in healthy chil dren; 5 children from this group with high level It was proposed to in troduce the described method into clinic for the study of the processe s of brain's epileptization in process-of development of diseases of n ervous system, accompanied by convulsions or paroxysmal states.