SELF-ASSEMBLING BIS-DENDRITIC PEPTIDES - DESIGN, SYNTHESIS AND CHARACTERIZATION OF OXALYL-LINKED BIS-GLUTAMYL PEPTIDES [GLU(N)(CO2ME)(N-CO-](2) N=1, 3, 7(1))

Three generations of glutamic acid dendrons [Glu(n)(CO2Me)(n+1); n = 1 , 3, 7] have been joined together head-to-head by an oxalyl unit to fo rm highly sterically congested bis-Glu-dendritic peptides with gelling properties. The single crystal X-ray structure of the first generatio n bis-dendritic peptide showed an extended hydrogen-bonded chiral tape with modest nonlinear optical activity. (C) Munksgaard 1998.