Authors
Citation
D. Bertwistle et A. Ashworth, FUNCTIONS OF THE BRGA1 AND BRCA2 GENES, Current opinion in genetics & development, 8(1), 1998, pp. 14-20
Citations number
62
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
ISSN journal
0959437X
Volume
8
Issue
1
Year of publication
1998
Pages
14 - 20
Database
ISI
SICI code
0959-437X(1998)8:1<14:FOTBAB>2.0.ZU;2-G
Abstract
Mutations in the BRCA1 and BRCA2 genes confer a high risk of breast ca
ncer development. Both genes encode very large proteins of unknown fun
ction but recent results suggest that they may have roles in transcrip
tional regulation and DNA repair. These advances offer the prospect of
understanding not only the normal cellular function of these genes bu
t also how their loss leads to tumour formation.