THE PATCHED GENE IN DEVELOPMENT AND CANCER

Authors
INGHAM PW
Citation
Pw. Ingham, THE PATCHED GENE IN DEVELOPMENT AND CANCER, Current opinion in genetics & development, 8(1), 1998, pp. 88-94
Citations number
49
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
8
Issue
1
Year of publication
1998
Pages
88 - 94
Database
ISI
SICI code
0959-437X(1998)8:1<88:TPGIDA>2.0.ZU;2-3
Abstract
The cloning of vertebrate homologues of the Drosophila segment polarit y gene patched has led to confirmation of a role for the multipass tra nsmembrane protein which it encodes as a receptor for secreted signall ing proteins of the Hedgehog family. In addition, human patched has be en identified as a tumour suppressor gene implicated in basal cell car cinomas and medullablastomas.