SARCOIDOSIS SECONDARY TO INHALATION OF MU RAL ISOLATION MATERIAL PARTICLES

Background. Sarcoidosis is a systemic disease defined by multiple gran ulomas. We report a case of sarcoidosis which occur concomitantly or s econdary to foreign body granuloma of the lung. Case report. A 50-year -old women presented with Lofgren syndrome, subcutaneous granulomatous nodular lesions on the arms and legs. Computed tomography revealed a foreign body granuloma of the lung centered on particles of mural isol ation material that the patient had inhaled accidentally. Analysis of the foreign body particles showed non crystalline silica, calcite mono hydrate and phenol resin. Discussion. Recent studies support the hypot hesis that sarcoidosis is an antigen-driven disease involving pulmonar y T-cell activation. The antigen-mediated reaction may be caused by in fectious agents, particularly mycobacteria, occupational and environme ntal agents (beryllium) or as in our observation following inhalation of mural isolation material particles.