PACHYDERMOPERIOSTOSIS WITH EXTRAMEDULLARY HEMATOPOIESIS WITHOUT MYELOFIBROSIS

Background. In three previous reports of primary hypertrophic osteoart hropathy, an associated extramedullary hematopoiesis was related to my elofibrosis. Case report. A 44-year-old male patient with primary hype rtrophic osteoarthropathy diagnosed when he was 34-year-old was referr ed to our hospital with an abdominal mass fortuitously detected. Discu ssion. The present case is unique for the patient developed an extrame dullary hematopoiesis without associated myelofibrosis. It suggests th e possible intervention of growth factors common to the skin fibroblas ts and the blood progenitor cells in the pathogenesis of primary osteo arthropathy.