SYNTHESES AND ANTITUMOR ACTIVITIES OF SPI N-LABELED 5-FLUORACIL DERIVATIVES

Authors
MAO MJ TIAN X CHEN YZ
Citation
Mj. Mao et al., SYNTHESES AND ANTITUMOR ACTIVITIES OF SPI N-LABELED 5-FLUORACIL DERIVATIVES, Gaodeng xuexiao huaxue xuebao, 19(3), 1998, pp. 395-398
Citations number
6
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
19
Issue
3
Year of publication
1998
Pages
395 - 398
Database
ISI
SICI code
0251-0790(1998)19:3<395:SAAAOS>2.0.ZU;2-X
Abstract
Ten new spin-labeled derivatives of 5-fluorouracil (2a-8) were synthes ized by introducing four kinds of stable nitroxyl radicals into N-1 an d N-3 site of 5-Fu. The structures of and elemental analysis. The anti tumor activities of these compounds were tested to be against KB, HCT- 8 and A2780. The preliminary results showed that the antitumor activit ies of compounds 2a and 3a were stronger than that of 5-Fu and were si milar to that of HCFU.