This study was devised to determine whether blood loss for sequential
bilateral knee arthroplasties was the same for the first and second kn
ees. Twenty-eight patients who underwent this procedure were studied a
long with a control group of patients who underwent unilateral knee ar
throplasties. Blood loss was greater in the second knee by a mean of 3
23 mL (P < .05). The control group and the first knee showed no signif
icant difference in blood loss. Analysis of clotting studies showed a
prolongation of prothrombin time, activated partial thromboplastin lim
e, and thrombin time after release of the first tourniquet. Possible r
easons for this greater blood loss are discussed.