P. Subramani et al., N-(4-BENZYLIDENE-2-METHYL PHENYL-5-OXO-IMIDAZOLIN-1-YL)-ACETOACETAMIDES AND THEIR BETA-(4-SUBSTITUTED PHENYL)-AZO ANALOGS/, Indian Journal of Heterocyclic Chemistry, 6(3), 1997, pp. 215-218
Condensation of -4-benzylidene-2-methyl/phenyl-5-(4H)-imidazolines (1a
,b) with ethyl acetoacetate gave corresponding thyl/phenyl-5-oxo-imida
zolin-1-yl)-acetoacetamides (2,3). These were reacted with diazotised
arylamines (A) to afford corresponding azo analogs (4-13). The compoun
ds were characterized and evaluated for their analgesic, antiinflammat
ory, antihistaminic and antimicrobial properties. Some of these compou
nds were found to exhibit good analgesic and antiinflammatory properti
es.