STATISTICAL-ANALYSIS OF SIGNALS FROM AN INTRACAVITARY PROBE IN A DISEASED HEART

A model study introduces the use of statistical signal processing to a nalyse the signals from an intracavitary probe. A complete derivation is given for the detection of one type of arrhythmogenic substrate, my ocardial infarctions (MIs). Both the use of statistical signal process ing and the detection of VT substrates, as opposed to activation maps, are unique. A quasi-stationary electromagnetic model with simplified geometry is presented. The model is used to simulate ventricular pacin g in the presence of MI. The likelihood ratio is used for detection. A tabulation of the results from this model shows that an intracavitary probe can be used to detect MIs as small as 400 mm(2) in 1 mV of nois e with a detectability index of 0.495, where 0.5 indicates perfect det ection. Sensitivity to noise can be reduced by analysing multiple hear t beats. The results are only slightly affected by changing the probe from a cage frame design, which mechanically supports the electrodes o n thin spokes, to a balloon design, which supports the electrodes on t he surface of an insulating balloon.