Re. Wellinger et Jm. Sogo, IN-VIVO MAPPING OF NUCLEOSOMES USING PSORALEN-DNA CROSS-LINKING AND PRIMER EXTENSION, Nucleic acids research, 26(6), 1998, pp. 1544-1545
By the use of psoralen crosslinking and primer extension, a method was
developed which allows the analysis of chromatin structure in vivo. U
sing a yeast minichromosome, >9 nucleosomes were mapped with a resolut
ion of at least +/-30 bp.