LACK OF EFFECT OF HYDROCORTISONE TREATMENT ON D-FENFLURAMINE-MEDIATEDPROLACTIN-RELEASE

The prolactin responses to the serotonin (5-HT) releasing agent d-fenf luramine (30 mg orally) were studied in 11 male normal volunteers afte r administration of hydrocortisone (20 mg orally, twice daily for 10 d ays) using a double-blind, placebo-controlled, cross-over design. Whil e hydrocortisone treatment significantly elevated 24-h urinary cortiso l excretion, it did not lower the prolactin response to d-fenfluramine . Plasma levels of d-fenfluramine and d-norfenfluramine were not alter ed by hydrocortisone treatment. These findings show that following 10 days administration of hydrocortisone, the prolactin responses to d-fe nfluramine are not changed.