Confusion in the elderly patient is usually a symptom of delirium or d
ementia, but it may also occur in major depression and psychoses. Unti
l another cause is identified the confused patient should be assumed t
o have delirium, which is often reversible with treatment of the under
lying disorder. Causes of delirium include metabolic disorders, infect
ions and medications. Thyroid dysfunction, vitamin deficiencies and no
rmal-pressure hydrocephalus are some potentially reversible causes of
dementia. Major irreversible causes include Alzheimer's disease, centr
al nervous system damage and human immunodeficiency virus infection. A
ll but the rarest causes of confusion can usually be identified based
on the complete history, medication review, physical examination, ment
al status evaluation and laboratory evaluation with longitudinal reeva
luation.