POLYFUNCTIONALIZED PYRROLIDINONES VIA THE COUPLING OF N,N-DISUBSTITUTED BETA-AMINO ESTERS WITH ETHYL GLYOXALATE

Authors
MA DW JIANG JQ
Citation
Dw. Ma et Jq. Jiang, POLYFUNCTIONALIZED PYRROLIDINONES VIA THE COUPLING OF N,N-DISUBSTITUTED BETA-AMINO ESTERS WITH ETHYL GLYOXALATE, Tetrahedron : asymmetry, 9(4), 1998, pp. 575-579
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
4
Year of publication
1998
Pages
575 - 579
Database
ISI
SICI code
0957-4166(1998)9:4<575:PPVTCO>2.0.ZU;2-J
Abstract
N,N-Disubstituted amino esters were prepared by stereoselective conjug ate addition of (S)- or (R)-lithium N-benzyl-N-alpha-methylbenzylamide to alpha,beta-unsaturated esters. The couplings of the formed esters with ethyl glyoxalate followed by hydrogenation afforded 5-alkyl-4-car boethoxy-3-hydroxy-pyrrolid stereoselectively. (C) 1998 Elsevier Scien ce Ltd. All rights reserved.