LIPASE-CATALYZED KINETIC RESOLUTION OF THREO-CONFIGURED 1,2-DIOLS - ACOMPARATIVE-STUDY OF TRANSESTERIFICATION VERSUS HYDROLYSIS

Authors
ADAM W DIAZ MT SAHAMOLLER CR
Citation
W. Adam et al., LIPASE-CATALYZED KINETIC RESOLUTION OF THREO-CONFIGURED 1,2-DIOLS - ACOMPARATIVE-STUDY OF TRANSESTERIFICATION VERSUS HYDROLYSIS, Tetrahedron : asymmetry, 9(4), 1998, pp. 589-598
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
4
Year of publication
1998
Pages
589 - 598
Database
ISI
SICI code
0957-4166(1998)9:4<589:LKROT1>2.0.ZU;2-S
Abstract
The kinetic resolution of the alpha,beta-unsaturated vicinal diols 3 h as been investigated by irreversible transesterification in organic me dia and by hydrolysis of the corresponding diacetates 6 (Scheme 1). Th e best results were obtained in the hydrolysis of the diacetates with the lipase CAL-B from Candida antarctica as a catalyst. (C) 1998 Elsev ier Science Ltd. All rights reserved.