K. Shoudai et al., ISOLATION OF CDNA-ENCODING A NOVEL HUMAN CC-CHEMOKINE NCC-4 LEC/, Biochimica et biophysica acta, N. Gene structure and expression, 1396(3), 1998, pp. 273-277
We have determined the entire sequence of human cDNA encoding a novel
CC chemokine NCC-4 by 5' and 3' RACE methods. Two types of transcripts
, 579 bp and 1503 bp long, respectively, are generated through alterna
tive polyadenylation sites. Both species contain an open reading frame
encoding 120 amino acids with 19-38% identity to other human CC chemo
kines. The short and long transcripts are expressed highly selectively
in the liver at nearly equivalent levels. There seems to be one copy
of the gene per haploid genome. We now designate NCC-4 as LEC from liv
er-expressed chemokine. (C) 1998 Elsevier Science B.V.