T. Yoshioka et al., INFLUENCE OF CHEMOTHERAPY ON FDG UPTAKE BY HUMAN CANCER XENOGRAFTS INNUDE-MICE, The Journal of nuclear medicine, 38(5), 1997, pp. 714-717
This study evaluated the use of PET with F-18-2-deoxy-2-fluoro-D-gluco
se (F-18-FDG) for monitoring chemotherapy effects, using a human cance
r xenograft (poorly differentiated human gastric cancer) in vivo model
. Methods: Tumor F-18-FDG uptakes and sizes were measured after admini
strating mitomycin (MMC), cisplatin (CDDP) and adriamycin (ADR) to xen
ograft-bearing nude mice and compared with F-18-FDG tumor uptake and t
umor size in a non-therapy group. The correlation between the uptake a
nd size was also assessed. Results: The largest reduction in tumor siz
e after chemotherapy occurred in the MMC administered group, followed
by the CDDP case, with no reduction in the ADR group as compared to th
e controls, Fluorine-18-FDG tumor uptake after chemotherapy was also d
ecreased in the MMC and CDDP groups, in that order, but not in the ADR
case, With MMC and CDDP, size reduction became significant on Days 8
or 11, whereas F-18-FDG tumor uptake had already been decreased on Day
s 3 or 7, Conclusion: Fluorine-18-FDG uptake decreases in parallel to
the efficacy of anticancer agents and correlates with subsequent morph
ologic changes. We conclude that F-18-FDG PET tumor images are indeed
useful for monitoring the effects of cancer chemotherapy.