INFLUENCE OF CHEMOTHERAPY ON FDG UPTAKE BY HUMAN CANCER XENOGRAFTS INNUDE-MICE

Citation
T. Yoshioka et al., INFLUENCE OF CHEMOTHERAPY ON FDG UPTAKE BY HUMAN CANCER XENOGRAFTS INNUDE-MICE, The Journal of nuclear medicine, 38(5), 1997, pp. 714-717
Citations number
35
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
01615505
Volume
38
Issue
5
Year of publication
1997
Pages
714 - 717
Database
ISI
SICI code
0161-5505(1997)38:5<714:IOCOFU>2.0.ZU;2-P
Abstract
This study evaluated the use of PET with F-18-2-deoxy-2-fluoro-D-gluco se (F-18-FDG) for monitoring chemotherapy effects, using a human cance r xenograft (poorly differentiated human gastric cancer) in vivo model . Methods: Tumor F-18-FDG uptakes and sizes were measured after admini strating mitomycin (MMC), cisplatin (CDDP) and adriamycin (ADR) to xen ograft-bearing nude mice and compared with F-18-FDG tumor uptake and t umor size in a non-therapy group. The correlation between the uptake a nd size was also assessed. Results: The largest reduction in tumor siz e after chemotherapy occurred in the MMC administered group, followed by the CDDP case, with no reduction in the ADR group as compared to th e controls, Fluorine-18-FDG tumor uptake after chemotherapy was also d ecreased in the MMC and CDDP groups, in that order, but not in the ADR case, With MMC and CDDP, size reduction became significant on Days 8 or 11, whereas F-18-FDG tumor uptake had already been decreased on Day s 3 or 7, Conclusion: Fluorine-18-FDG uptake decreases in parallel to the efficacy of anticancer agents and correlates with subsequent morph ologic changes. We conclude that F-18-FDG PET tumor images are indeed useful for monitoring the effects of cancer chemotherapy.