SYNTHESIS AND MASS-SPECTROMETRIC BEHAVIOR OF SOME NEW NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

Authors
FADDA AM PODDA G TEIJEIRA M URIARTE E FAVRETTO D DALPAOS M TRALDI P
Citation
Am. Fadda et al., SYNTHESIS AND MASS-SPECTROMETRIC BEHAVIOR OF SOME NEW NUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS, Rapid communications in mass spectrometry, 11(7), 1997, pp. 774-780
Citations number
9
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
11
Issue
7
Year of publication
1997
Pages
774 - 780
Database
ISI
SICI code
0951-4198(1997)11:7<774:SAMBOS>2.0.ZU;2-U
Abstract
The electron-impact (EI) mass spectrometric behaviour of a series of 8 -aza-purines derivatized with hydroxymethylcyclopentane and exhibiting cis-trans isomerization in the cyclopentane ring has been studied in detail with the aid of metastable-ion data. Specific fragmentation pro cesses, present in both EI and mass analysed ion kinetic energy spectr a of molecular species, allow characterization of the different pairs of stereoisomers. Contrary to what is observed in the case of purine a nalogs, the presence of a nitrogen atom in position 8 strongly inhibit s fragmentation processes related to the heterocycle. (C) 1997 by John Wiley & Sons, Ltd.