M. Gniazdowski et al., PHOTOREACTION OF FUROCOUMARINS WITH DNA IS SIMILARLY INHIBITED BY MINOR AND MAJOR GROOVE-INTERACTING LIGANDS, Il Farmaco, 52(11), 1997, pp. 653-655
It was found that methyl green, a major groove binding ligand and the
minor groove binding ligands, netropsin and 2,7-di-tert-butylproflavin
e inhibit, to a similar extend a monoadduct forming benzopsoralen and
monoadduct and diadduct forming derivatives of psoralen (8-methoxypsor
alen and 3,4'-dimethyl-8-methoxypsoralen). Caffeine exhibits an inhibi
tory effect on furocoumarin photobinding to DNA at 10(3) fold higher c
oncentration. Together with the previously published results it is con
cluded that both occupancy of the major and minor groove as well as in
tercalation hinder photobinding of furocoumarins to DNA.