EVALUATION OF ANTIMYCOBACTERIAL AND ANTICONVULSANT ACTIVITIES OF NEW -(4-FLUOROBENZOYL)-4-SUBSTITUTED-THIOSEMICARBAZIDE AND SUBSTITUTED-2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONE DERIVATIVES

Some new 1-(4-fluorobenzoyl)-4-alkyl/arylthiosemicarbazide (2a-g), 5-( 4-fluorophenyl)4-alkyl/aryl-2,4-dihydr-3H 1,2,4-triazole-3-thione (3a- g) derivatives, hio)-5-(4-fluorophenyl)-4-phenyl-4H-1,2,4-triazole (3h ) and l)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (3i) were pre pared and tested for their antimycobacterial and anticonvulsant activi ties. The structure of compounds was confirmed by elemental analyses a nd spectroscopic techniques. The antimycobacterial activity of the syn thesized compounds was investigated against M. fortiutum ATCC 6841 and most of them were found active against the above strain with MIC valu es of 64 or 32 mu g/ml. The anticonvulsant activity of the 2d, 3d-i wa s determined against pentylenetetrazole induced seizures. 3f-i showed anticonvulsant activity (10 to 30% protection).