''Theoretical pluralism'' obtains when there are good evidential reaso
ns for accommodating multiple theories of the same domain. Issues of '
'relative significance'' often arise in connection with the investigat
ion of such domains. In this paper, I describe and give examples of th
eoretical pluralism and relative significance issues. Then I explain w
hy theoretical pluralism so often obtains in biology-and why issues of
relative significance arise-in terms of evolutionary contingencies an
d the paucity or lack of laws of biology. Finally, I turn from explana
tion to justification, and raise questions about the purpose and value
of concerns and disagreements about relative significance.