ACUTE EFFECTS OF DISTAL PANCREATECTOMY ON PORTAL AND PERIPHERAL-BLOODINSULIN CONCENTRATIONS IN PATIENTS UNDERGOING TOTAL GASTRECTOMY

The influence of distal pancreatectomy on portal and peripheral blood immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) concent rations was evaluated in patients undergoing total gastrectomy. There were 22 patients studied, 12 of whom did not undergo distal pancreatec tomy (group 1), and 10 who did (group 2), In group 2, the increase in portal blood IRI concentrations after a glucose infusion of 25 g over 30 min was suppressed, and reelevation of the portal blood IRG concent ration after the glucose-induced depression tvas inhibited compared to group 1, In contrast, the peripheral blood IRI concentration did not reflect these changes in the portal blood IRI concentration, The rise in the arterial ketone body ratio (AKBR) and the fall in the total ket one body concentration after glucose infusion were also attenuated aft er distal pancreatectomy in group 2. These findings suggest that dista l pancreatectomy has an immediate suppressive effect on the pancreatic secretion of insulin and glucagon, and might disturb metabolism in th e liver.