EFFECTS OF OIL-SOLUBLE ORGANOSULFUR COMPOUNDS FROM GARLIC ON DOXORUBICIN-INDUCED LIPID-PEROXIDATION

Clinical efficacy of doxorubicin is compromised due to free radical ge neration leading to cardiac toxicity. Oil-soluble organosulfur compoun ds, diallyl sulfide (DAS), diallyl disulfide (DADS), dipropyl sulfide (DPS) and dipropyl disulfide (DPDS), present in garlic were examined f or their antiperoxidant effects. DADS inhibited liver microsomal lipid peroxidation induced by NADPH, ascorbate and doxorubicin. DAS, DPS an d DPDS were ineffective inhibitors of liver microsomal lipid peroxidat ion. DADS could be used in combination with doxorubicin to protect oxi dative injuries to improve the clinical efficacy of doxorubicin. [(C) 1998 Rapid Science Ltd.].