C. Dwivedi et al., EFFECTS OF OIL-SOLUBLE ORGANOSULFUR COMPOUNDS FROM GARLIC ON DOXORUBICIN-INDUCED LIPID-PEROXIDATION, Anti-cancer drugs, 9(3), 1998, pp. 291-294
Clinical efficacy of doxorubicin is compromised due to free radical ge
neration leading to cardiac toxicity. Oil-soluble organosulfur compoun
ds, diallyl sulfide (DAS), diallyl disulfide (DADS), dipropyl sulfide
(DPS) and dipropyl disulfide (DPDS), present in garlic were examined f
or their antiperoxidant effects. DADS inhibited liver microsomal lipid
peroxidation induced by NADPH, ascorbate and doxorubicin. DAS, DPS an
d DPDS were ineffective inhibitors of liver microsomal lipid peroxidat
ion. DADS could be used in combination with doxorubicin to protect oxi
dative injuries to improve the clinical efficacy of doxorubicin. [(C)
1998 Rapid Science Ltd.].