A. Panossian et al., PHARMACOLOGICAL ACTIVITY OF PHENYLPROPANOIDS OF THE MISTLETOE, VISCUM-ALBUM L., HOST - PYRUS CAUCASICA FED, Phytomedicine, 5(1), 1998, pp. 11-17
Although a great number of compounds have been isolated from Viscum al
bum (mistletoe, Viscaceae), none of them could be clearly shown to pos
sess the established hypotensive, vasodilator, cardiotonic and antitum
or activity of alcoholic preparations. In the course of our investigat
ion of Armenian mistletoe Viscum album, host: Pyrus caucasica, which h
as been used in Armenian traditional medicine for the treatment of car
diovascular diseases and for stimulation of the immune system, four ph
enylpropanoid glycosides were isolated from EtOH-extract: coniferyl al
cohol 4-O-beta-D-glucopyranoside (coniferin), syringenin 4-O-beta-D-gl
ucopyranoside (syringin), and coniferylalcohol- and syringenin 4-O-bet
a-D-apiofuranosyl (1-->2)-beta-D-glucopyranosides. The structures were
established on the basis of the spectral and chemical data. All subst
ances inhibited ADP-induced platelet aggregation, and the apiosyldigly
cosides only inhibited leukotriene B-4 release from TPA and calcium io
nophore A-23187 stimulated human granulocytes. It is suggested that an
antitumoral effect of ethanolic extract of Viscum album could be asso
ciated with the inhibition of protein kinase C (PKC).