EXPRESSION OF LARGE GENOMIC CLONES IN TRANSGENIC MICE - NEW INSIGHTS INTO APOLIPOPROTEIN-B STRUCTURE, FUNCTION AND REGULATION

Authors
MCCORMICK SPA NIELSEN LB
Citation
Spa. Mccormick et Lb. Nielsen, EXPRESSION OF LARGE GENOMIC CLONES IN TRANSGENIC MICE - NEW INSIGHTS INTO APOLIPOPROTEIN-B STRUCTURE, FUNCTION AND REGULATION, Current opinion in lipidology, 9(2), 1998, pp. 103-111
Citations number
60
Categorie Soggetti
Peripheal Vascular Diseas",Biology,"Endocrynology & Metabolism
Journal title
Current opinion in lipidology → ACNP
ISSN journal
09579672
Volume
9
Issue
2
Year of publication
1998
Pages
103 - 111
Database
ISI
SICI code
0957-9672(1998)9:2<103:EOLGCI>2.0.ZU;2-9
Abstract
Extensive manipulation of the apolipoprotein B gene in yeast and bacte rial artificial chromosome clones and subsequent expression of these c lones in transgenic mice have provided fresh insights into several asp ects of apolipoprotein B biology, including the identification of sequ ences important for lipoprotein (a) assembly, the demonstration that i ntestinal expression of apolipoprotein B is controlled by DNA sequence s >50 kb from the gene, and the extraordinary finding that apolipoprot ein B is expressed in the heart. (C) 1998 Rapid Science Ltd.