The objective of this study was to evaluate the features and calculate
the frequency of sex-reassigned subjects who had applied for reversal
to their biological sex, and to compare these with non-regretful subj
ects. An inception cohort was retrospectively identified consisting of
all subjects with gender identity disorder who were approved for sex
reassignment in Sweden during the period 1972-1992. The period of time
that elapsed between the application and this evaluation ranged from
4 to 24 years. The total cohort consisted of 218 subjects. The results
showed that 3.8% of the patients who were sex reassigned during 1972-
1992 regretted the measures taken. The cohort was subdivided according
to the presence or absence of regret of sex reassignment, and the two
groups were compared. The results of logistic regression analysis ind
icated that two factors predicted regret of sex reassignment, namely l
ack of support from the patient's family, and the patient belonging to
the non-con group of transsexuals. In conclusion, the results show th
at the outcome of sex reassignment has improved over the years. Howeve
r, the identified risk factors indicate the need for substantial effor
ts to support the families and close friends of candidates for sex rea
ssignment.