ASSIGNMENT OF INDIVIDUALS TO POPULATIONS USING MICROSATELLITES

Authors
Citation
Ku. Gotz et G. Thaller, ASSIGNMENT OF INDIVIDUALS TO POPULATIONS USING MICROSATELLITES, Journal of animal breeding and genetics, 115(1), 1998, pp. 53-61
Citations number
8
Categorie Soggetti
Agriculture Dairy & AnumalScience
ISSN journal
09312668
Volume
115
Issue
1
Year of publication
1998
Pages
53 - 61
Database
ISI
SICI code
0931-2668(1998)115:1<53:AOITPU>2.0.ZU;2-V
Abstract
The article presents two methods for the assignment of an anonymous DN A-sample re populations with, known allele frequencies at a number oi marker loci. The first method calculates the conditional probability f or the sample Eo belong to one of the two possible populations given t he complete marker genotype at several loci. The second method is a si mple test for thr sample to belong to a known population and is based on the distribution of complete marker genotype probabilities. Simulat ion studies were performed for the first method in order to estimate t he expected probability for two populations with random allele frequen cy differences. The results indicate that sis loci with four to five a lleles each are sufficient to obtain an expected probability of more t han 0.05 in 98.1 and 99.8 % of all possible situations. The simulation studies for the second method were used to estimate the power of the test for three different scenarios. The results show char with six loc i with five alleles per locus a power between 0.90 and 0.98 can be ach ieved. However, this is only true if the distribution of allele freque ncies in the known population is not extremely skewed.