FIV INDUCED ENCEPHALOPATHY - EARLY BRAIN-LESIONS IN THE ABSENCE OF VIRAL REPLICATION IN MONOCYTE MACROPHAGES - A PATHOGENETIC MODEL/

Authors
SILVOTTI L CORRADI A BRANDI G CABASSI A BENDINELLI M MAGNAN M PIEDIMONTE G
Citation
L. Silvotti et al., FIV INDUCED ENCEPHALOPATHY - EARLY BRAIN-LESIONS IN THE ABSENCE OF VIRAL REPLICATION IN MONOCYTE MACROPHAGES - A PATHOGENETIC MODEL/, Veterinary immunology and immunopathology, 55(4), 1997, pp. 263-271
Citations number
17
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
55
Issue
4
Year of publication
1997
Pages
263 - 271
Database
ISI
SICI code
0165-2427(1997)55:4<263:FIE-EB>2.0.ZU;2-8
Abstract
FIV induced encephalopathy represents a model for the study of the neu ropathogenesis of AIDS. It has yet to be determined whether massive vi ral replication is a prerequisite for the development of early brain l esions. Using a drug delivery system developed by us, we have shown th at early encephalic lesions appear in FIV infected subjects even when viral transport within the brain has been markedly reduced or blocked. (C) 1997 Elsevier Science B.V.