SYNTHESIS AND 5-ALPHA-REDUCTASE INHIBITORY ACTIVITIES OF BENZOFURAN DERIVATIVES WITH A CARBAMOYL GROUP

Authors
ISHIBASHI K NAKAJIMA K SUGIOKA Y SUGIYAMA M HAMADA T HORIKOSHI H NISHI T
Citation
K. Ishibashi et al., SYNTHESIS AND 5-ALPHA-REDUCTASE INHIBITORY ACTIVITIES OF BENZOFURAN DERIVATIVES WITH A CARBAMOYL GROUP, Bioorganic & medicinal chemistry letters, 8(6), 1998, pp. 561-566
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
6
Year of publication
1998
Pages
561 - 566
Database
ISI
SICI code
0960-894X(1998)8:6<561:SA5IAO>2.0.ZU;2-P
Abstract
A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbam oyl group at the 5 or 6 position of the benzofuran ring were synthesiz ed and evaluated for rat and human testosterone 5 alpha-reductase inhi bitory activities in vitro. They had inhibitory activities against bot h enzymes and the 6-carbamoyl derivatives tended to be more potent tha n the 5-carbamoyl compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.