SELECTIVE PHOTOCLEAVAGE OF SINGLE-STRANDED NUCLEIC-ACIDS BY CYCLOBISINTERCALAND MOLECULES

Authors
BLACKER AJ TEULADEFICHOU MP VIGNERON JP FAUQUET M LEHN JM
Citation
Aj. Blacker et al., SELECTIVE PHOTOCLEAVAGE OF SINGLE-STRANDED NUCLEIC-ACIDS BY CYCLOBISINTERCALAND MOLECULES, Bioorganic & medicinal chemistry letters, 8(6), 1998, pp. 601-606
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
6
Year of publication
1998
Pages
601 - 606
Database
ISI
SICI code
0960-894X(1998)8:6<601:SPOSNB>2.0.ZU;2-B
Abstract
Irradiation of mixtures of a single-stranded circular plasmid and of a double-stranded supercoiled DNA in presence of the cyclobisintercalan d compounds 2 or 3 shows that these reagents effect the selective phot ocleavage of the single-stranded entity. Furthermore, 2 also cleaves t RNAasp preferentially at single stranded domains. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.