POTENT HIV PROTEASE INHIBITORS INCORPORATING HIGH-AFFINITY P-2-LIGANDS AND (R)-(HYDROXYETHYLAMINO)SULFONAMIDE ISOSTERE

Authors
GHOSH AK KINCAID JF CHO WH WALTERS DE KRISHNAN K HUSSAIN KA KOO Y CHO H RUDALL C HOLLAND L BUTHOD J
Citation
Ak. Ghosh et al., POTENT HIV PROTEASE INHIBITORS INCORPORATING HIGH-AFFINITY P-2-LIGANDS AND (R)-(HYDROXYETHYLAMINO)SULFONAMIDE ISOSTERE, Bioorganic & medicinal chemistry letters, 8(6), 1998, pp. 687-690
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
6
Year of publication
1998
Pages
687 - 690
Database
ISI
SICI code
0960-894X(1998)8:6<687:PHPIIH>2.0.ZU;2-O
Abstract
Design and synthesis of a series of very potent nonpeptide HIV proteas e inhibitors are described. The inhibitors are derived from novel high affinity P-2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere. (C) 1998 Elsevier Science Ltd. All rights reserved.