DIIMIDAZO[1,2-C 4',5'-E]PYRIMIDINES - ADENOSINE AGONIST ACTIVITY DEMONSTRATED BY MICROPHYSIOMETRY/

Authors
CAMP D GREEN JM KAISER SM MONI RW TOWNSENDNICHOLSON A SCHOFIELD PR QUINN RJ
Citation
D. Camp et al., DIIMIDAZO[1,2-C 4',5'-E]PYRIMIDINES - ADENOSINE AGONIST ACTIVITY DEMONSTRATED BY MICROPHYSIOMETRY/, Bioorganic & medicinal chemistry letters, 8(6), 1998, pp. 691-694
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
6
Year of publication
1998
Pages
691 - 694
Database
ISI
SICI code
0960-894X(1998)8:6<691:D4-AAA>2.0.ZU;2-9
Abstract
Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2- c:4',5'-e]pyrimidines were agonists at the human adenosine A(1) recept or. (R)-(phenyl)-3H-diimidazo[1,2-c:4',5'-e]pyrimidine (2a) had an EC5 0 of 100 mu M and reached 90% of the E-max produced by R-PIA. (C) 1998 Elsevier Science Ltd. All rights reserved.