GRANULE CELL DISPERSION IS CORRELATED WITH EARLY EPILEPTIC EVENTS IN HUMAN TEMPORAL-LOBE EPILEPSY

Authors
LURTON D ELBAHH B SUNDSTROM L ROUGIER A
Citation
D. Lurton et al., GRANULE CELL DISPERSION IS CORRELATED WITH EARLY EPILEPTIC EVENTS IN HUMAN TEMPORAL-LOBE EPILEPSY, Journal of the neurological sciences, 154(2), 1998, pp. 133-136
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Journal of the neurological sciences → ACNP
ISSN journal
0022510X
Volume
154
Issue
2
Year of publication
1998
Pages
133 - 136
Database
ISI
SICI code
0022-510X(1998)154:2<133:GCDICW>2.0.ZU;2-D
Abstract
Granule cell dispersion (GCD) into the dentate gyrus (DG) molecular la yer was observed in hippocampal specimens in 10 out of 22 cases of hum an non-lesional temporal lobe epilepsy (TLE) and was associated with h ippocampal sclerosis (HS). The presence of GCD was significantly linke d to events of epileptic nature arising during the first 4 years of li fe but not with the durations of epilepsy, nor the number of seizures. Dispersion could be induced by seizure-linked structural plasticity o ccurring during a specific early permissive period. (C) 1998 Elsevier Science B.V.