ADHERENCE TO AND PENETRATION OF HUMAN INTESTINAL CACO-2 EPITHELIAL-CELL MONOLAYERS BY PSEUDOMONAS-AERUGINOSA

Authors
HIRAKATA Y IZUMIKAWA K YAMAGUCHI T IGIMI S FURUYA N MAESAKI S TOMONO K YAMADA Y KOHNO S YAMAGUCHI K KAMIHIRA S
Citation
Y. Hirakata et al., ADHERENCE TO AND PENETRATION OF HUMAN INTESTINAL CACO-2 EPITHELIAL-CELL MONOLAYERS BY PSEUDOMONAS-AERUGINOSA, Infection and immunity, 66(4), 1998, pp. 1748-1751
Citations number
26
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
4
Year of publication
1998
Pages
1748 - 1751
Database
ISI
SICI code
0019-9567(1998)66:4<1748:ATAPOH>2.0.ZU;2-0
Abstract
Clinical isolates of Pseudomonas aeruginosa from blood adhered to and penetrated intestinal Caco-2 cell monolayers to a greater degree than did isolates from sputum, with a concomitant drastic decrease in trans epithelial electrical resistance. PAO-PR1, an avirulent exotoxin A mut ant of PAO1, did not cause a decrease in the resistance. The Caco-2 mo nolayer system may be useful for the evaluation of certain P. aerugino sa virulence factor activities.