AGENTS THAT INHIBIT RHO, RAC, AND CDC42 DO NOT BLOCK FORMATION OF ACTIN PEDESTALS IN HELA-CELLS INFECTED WITH ENTEROPATHOGENIC ESCHERICHIA-COLI

Authors
BENAMI G OZERI V HANSKI E HOFMANN F AKTORIES K HAHN KM BOKOCH GM ROSENSHINE I
Citation
G. Benami et al., AGENTS THAT INHIBIT RHO, RAC, AND CDC42 DO NOT BLOCK FORMATION OF ACTIN PEDESTALS IN HELA-CELLS INFECTED WITH ENTEROPATHOGENIC ESCHERICHIA-COLI, Infection and immunity, 66(4), 1998, pp. 1755-1758
Citations number
10
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
4
Year of publication
1998
Pages
1755 - 1758
Database
ISI
SICI code
0019-9567(1998)66:4<1755:ATIRRA>2.0.ZU;2-4
Abstract
Enteropathogenic Escherichia coli (EPEC) induces formation of actin pe destals in infected host cells. Agents that inhibit the activity of Rh o, Rac, and Cdc42, including Clostridium difficile toxin B (ToxB), com pactin, and dominant negative Rho, Rac, and Cdc42, did not inhibit for mation of actin pedestals. In contrast, treatment of HeLa cells with T oxB inhibited EPEC invasion. Thus, Rho, Rac, and Cdc42 are not require d for assembly of actin pedestals; however, they may be involved in EP EC uptake by HeLa cells.